Our team is dedicated to employing bioinformatics approaches to elucidate protein functional and spatioal omics, including the regulation of post-translational modifications and the spatial localization features of proteins within cells and tissues along with their dynamic changes. We develop data resources and computational methods to investigate the dynamic alterations in protein post-translational modifications and spatial localization during tumorigenesis. By integrating these findings with specific clinical questions, we further explore the functional implications, underlying mechanisms, and targeting strategies associated with these aberrant protein dynamics.